DNA is a Biomacromolecule which has electric conductivity through a π stacking orbital, self assemble property and highly biocompatibility. Since it is easy to synthesize in large quantity, DNA application is widely expected in the fields of bioengineering. We are studying about flow dynamics and mechanical property of DNA both by theoretical and experimental approaches.

Figure 1 poly (dA)・poly (dT) DNA

Development of next generation DNA sequencer is expected to use for a tailor made medicine in the future. We focus on the measurement of single biomacromolecule in order to create the basic technology of a sequencer. Especially flow dynamics of biomacromolecule in micro/nano scale structure is observed by the use of fluorescent microscope.

Figure 2 DNA flown in nanochannel	Figure 3 Fluorescent image of λDNA

Electronic wavefunctions in DNA molecules which consist of G, C, A, and T can be visualized by the ab initio methods, shown by red- and blue-colored regions in the figures below. Furthermore, the time evolution of the wavefunction suggests the electron flow dynamics against external perturbations. We have developed our own methods in order to investigate the electronic responsiveness in DNAs. [1]

Figure 4 Electronic distribution and electrostatic potential	Figure 5 Dynamics of electronic wavefunction

You can see details in:

Kentaro DOI, Toru YONEBAYASHI, and Satoyuki KAWANO, Perturbation Theory Analysis for Electronic Response of DNA Base Pairs, J. Mol. Struct.: THEOCHEM, Vol. 939 (2010), pp. 97-105.